Synology DiskStation DS1621+ NAS Server for Business with Ryzen CPU
Bottom line: The Synology DiskStation DS1621+ NAS Server for Business with Ryzen CPU is a specs-and-price decision rather than a crowd-consensus one in the external storage category. Check the specification table below against one or two close alternatives — on price and spec fit, not on star ratings.
As an Amazon Associate, SpecPicks earns from qualifying purchases. Full disclosure →
Pros & Cons
Pros
- ✓ Synology NAS chassis comes in a sealed box.
- ✓ Backed by Synology's warranty and support channels
Cons
- ✗ Check the listed dimensions, connectors and platform compatibility against your setup before ordering
- ✗ Price, stock, shipping and returns are set by the retailer and may have changed since this page was last updated
Manufacturer description
Synology DiskStation DS1621+, made for a variety of server roles such as backup, file storage, email servers, and domain controllers!Form Factor: NAS Tower ServerInternal File System Format: EXT4, BtrfsPorts: 4 x RJ-45 1GbE LAN Port (with Link Aggregation / Failover support); 3 x USB 3.2 Port; 2 x eSATA PortProcessor: Ryzen V1500B Quad-Core 2.2GHz 4MB CPUMemory: 32GB DDR4 PC4-21300 2666MHz SO-DIMMsFile Storage: 12TB (6 x 2TB) SATA III Solid State Drives for Ultra Fast StoragePower: Single Power SupplyOperating System: Synology DSM SoftwareOperating System Features: iSCSI Target Protocol…
SpecPicks Verdict
SpecPicks scored Synology DiskStation DS1621+ NAS Server for Business with Ryzen CPU using a rating × review-volume × price-fit model applied to published specs and reviews across the external storage category. Synology's external storage lineup sits within the broader category mid-tier; price and specs are the deciding factors over brand loyalty here. Judge it on the specification table and the price rather than on sentiment: check the figures that decide your use case, then put it side-by-side with two or three close alternatives in the Compare tool before clicking through.
Common buyer scenarios for external storage of this kind: matching it to an existing build, replacing a failing part, or upgrading from a previous-generation equivalent. Check the spec table below against your current setup — particularly socket / form-factor / power-rating fields — and confirm compatibility on the retailer's listing before purchase. Prices and stock are set by the retailer and may have moved since this page was last updated.
Key Features
- Synology DiskStation DS1621+, made for a variety of server roles such as backup, file storage, email servers, and domain controllers!
- Ryzen V1500B Quad-Core 2.2GHz 4MB CPU; 32GB DDR4 PC4-21300 2666MHz SO-DIMMs; File Storage: 12TB (6 x 2TB) SATA III Solid State Drives for Ultra Fast Storage; 4 x RJ-45 1GbE LAN Port (with Link Aggregation / Failover support); 3 x USB 3.2 Port; 2 x eSATA Port
- Features: iSCSI Target Protocol, Cache Acceleration (2 available M.2 SSD Slots), Virtual Machine Manager, Synology High Availability, Synology MailPlus, Central Management System, Security Advisor, AES 256-bit Encryption, 2 Factor Authentication, Cloud Station Suite, 4K Multimedia Server role, Active Backup for VMware and Windows, Synology Drive, Active Backup for Office 365 and G Suite, Surveillance Station role, Collaboration Suite, and many more
- Synology NAS chassis comes in a sealed box.
- Hard drives and memory upgrades included separately NOT installed, installation required.
Full Specifications
| Brand | Synology |
|---|---|
| Color | Black |
| Unit Count | 6 Count |
| Connectivity | USB |
| Storage Volume | 12 TB |
| Number of Items | 1 |
| Number of Packs | 6 |
| Compatible Devices | Server |
| Warranty Description | Manufacturer |
| Full listing title | Synology DiskStation DS1621+ NAS Server for Business with Ryzen CPU, 32GB Memory, 12TB SSD Storage, DSM Operating System, iSCSI Target Ready |
Ready to buy?
Synology DiskStation DS1621+ NAS Server for Business with Ryzen CPU, 32GB Memory, 12TB SSD Storage, DSM Operating System, iSCSI Target Ready is listed on Amazon. Price, availability, shipping and returns are set by Amazon and its sellers — check the listing for current terms. SpecPicks earns a small commission on qualifying purchases — thank you for supporting independent review work.
Related External Storage
More guides & deep dives from the SpecPicks archive
Browse all articles & guides →- The Complete Voodoo5 5500 AGP Driver Guide (2026 Edition)
- Best Retro Handhelds in 2026 — From $35 to $500
- Best Budget Gaming PC Build 2026 — ~$1,000 ($800 on Sale)
- Emulation Hardware in 2026: FPGA, Software, and Cart-Reader Ecosystems
- Best 1440p Gaming GPUs in 2026
- RTX 4070 Super vs RX 7800 XT — Which to Buy in 2026
- How to Build a Windows 98 Retro PC in 2026
More reviews from the SpecPicks archive
Browse all reviews →- Ryzen 9 9950X3D vs Core Ultra 9 285K
- How to run Qwen 3 32B on Apple M3 Ultra
- NEEWER 18" vs UBeesize 22" Ring Light for Webcam Streaming (2026)
- How to run Qwen 3 32B on NVIDIA GeForce RTX 4090
- Best Budget Streaming Setup for Beginners in 2026
- GeForce 4 Ti 4600 AGP in 2026: Period-Correct Win98 Install Guide
- Best Gaming Monitor Under $400 in 2026: 5 Top Picks
- Best Raspberry Pi for a Touchscreen Home Dashboard in 2026
- 9800X3D Build: RTX 5080 vs 5070 Ti vs 9070 XT at 1440p
- RTX 3060 12GB vs RTX 4060 Ti 16GB for Qwen2.5-Coder 14B (2026)
- Best GPU for Ryzen 5 5500 in 2026 (Budget to 1440p)
- GLM-5.2 vs Frontier Models on GDPval-AA: What It Means for Local Builders
- RTX 5090 AI Build Guide: CPU, RAM, PSU & Cooling for Local Inference
- Ryzen 5600G vs 5700X vs 5800X: Best CPU for a 1080p Gaming Build (2026)
- 2002 GeForce 4 Ti Win98 Build: CompactFlash Storage Done Right
- Best CPU for Local LLM Inference in 2026: Ryzen 7 5800X vs 5700X vs 5600G
- Best SATA SSD for an AM4 Budget Build: BX500 vs 870 EVO vs WD Blue
- Blue Yeti vs HyperX QuadCast 2 S: Best Streaming Mic 2026
- Qwen3.8 Max vs Claude Opus 4.8: What the Cost-Per-Task Gap Means for Local Rigs
- AMD Radeon RX 9070 GRE Review: Thoroughly Midrange
- Gemini-SQL2 Tops Text-to-SQL: Can an RTX 3060 Run a Local SQL Model?
- Sound BlasterX G6 on a Retro PC: Bringing Modern DAC Quality to Pentium III and Athlon XP Builds
- AMD Ryzen AI Max+ 395 vs Mac Studio M4 Max for Local LLM Inference
- 18 LLMs Benchmarked on OCR: Why Cheaper Models Often Win
Earliest SpecPicks reviews
Browse full archive →- Best GPU for Llama 3.1 8B (2026)
- Best GPU for Qwen 3 14B (2026)
- Best GPU for Qwen 3 32B (2026)
- Best GPU for Llama 3.1 70B (2026)
- Best GPU for DeepSeek-R1 32B (2026)
- Best GPU for Llama 3.1 405B (2026)
- How to run Llama 3.1 8B on NVIDIA GeForce RTX 5090
- How to run Qwen 3 14B on NVIDIA GeForce RTX 5090
- How to run Qwen 3 32B on NVIDIA GeForce RTX 5090
- How to run Llama 3.1 70B on NVIDIA GeForce RTX 5090
- How to run DeepSeek-R1 32B on NVIDIA GeForce RTX 5090
- How to run Llama 3.1 8B on NVIDIA GeForce RTX 4090