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Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System
Synology

Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU

Bottom line: The Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU is a specs-and-price decision rather than a crowd-consensus one in the nas & home servers category, priced around $4,659.00 on Amazon as of 2026-10-21 04:22 UTC. Check the specification table below against one or two close alternatives — on price and spec fit, not on star ratings.

$4659.00

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Buy on Amazon — $4,659.00 Compare to similar nas & home servers

By , Founder & Editor-in-Chief · Listing data updated

Mike Perry — Hardware researcher since 2014. For NAS and home-server hardware, synthesises manufacturer specs and independent reviews rather than first-hand lab testing. Core beat: GPU performance across gaming, rendering, and local-LLM inference.

*Price sourced from Amazon.com. Last updated 2026-10-21. Price and availability subject to change.

Pros & Cons

Pros

  • ✓ Synology NAS chassis comes in a sealed box.
  • ✓ Backed by Synology's warranty and support channels

Cons

  • ✗ Check the listed dimensions, connectors and platform compatibility against your setup before ordering
  • ✗ Price, stock, shipping and returns are set by the retailer and may have changed since this page was last updated

Manufacturer description

Synology DiskStation DS1621+ made for a large assortment of server functions, such as iSCSI targets backup, file storage, email servers, & domain controllers.Form Factor: NAS Tower ServerInternal File System Format: EXT4, BtrfsPorts: 4 x RJ-45 1GbE LAN Ports (with Link Aggregation/ Failover support); 3 x USB 3.2 Ports; 2 x eSATA Ports; Btrfs File System for Advanced LUN iSCSI ServiceProcessor: Ryzen V1500B 4-Core 2.2GHz CPUMemory: 32GB DDR4 ECC SODIMM MemoryStorage: 48TB (6 x 8TB) SATA HDDs for High-Capacity StoragePower: Single Power SupplyOperating System: Synology DSM SoftwareIdeal for VM…

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SpecPicks Verdict

SpecPicks scored Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU using a rating × review-volume × price-fit model applied to published specs and reviews across the nas & home servers category. Synology's nas & home servers lineup sits within the broader category mid-tier; price and specs are the deciding factors over brand loyalty here. Judge it on the specification table and the price rather than on sentiment: check the figures that decide your use case, then put it side-by-side with two or three close alternatives in the Compare tool before clicking through.

Common buyer scenarios for nas & home servers of this kind: matching it to an existing build, replacing a failing part, or upgrading from a previous-generation equivalent. Check the spec table below against your current setup — particularly socket / form-factor / power-rating fields — and confirm compatibility on the retailer's listing before purchase. Prices and stock are set by the retailer and may have moved since this page was last updated.

Key Features

  • Synology DiskStation DS1621+, made for a variety of server roles, such as iSCSI targets backup, large file storage, email servers, and domain controllers. Powerful, high-capacity, scalable storage that fits in any environment. A powerhouse capable of fitting into small and medium business environments with intensive, multi-user workloads.
  • Ryzen V1500B Quad-Core 2.2GHz CPU; 32GB DDR4 ECC SODIMM Memory; M.2 Storage: 1TB (2 x 500GB) M.2 Solid State Drives for Ultra-Fast Storage; File Storage: 48TB (6 x 8TB) SATA HDDs for High-Capacity Storage; 4 x RJ-45 1GbE LAN Ports (with Link Aggregation / Failover support); 3 x USB 3.2 Ports; 2 x eSATA Ports
  • Features: iSCSI Target Protocol, Cache Acceleration, Virtual Machine Manager, Synology High Availability, Synology MailPlus, Central Management System, Security Advisor, AES 256-bit Encryption, 2 Factor Authentication, Cloud Station Suite, 4K Multimedia Server role, Active Backup for VMware and Windows, Synology Drive, Active Backup for Office 365 and G Suite, Surveillance Station role, Collaboration Suite, and many more
  • Synology NAS chassis comes in a sealed box.
  • Hard drives and memory upgrades included separately, NOT installed, installation required.

Full Specifications

BrandSynology
Unit Count1 Count
ConnectivityUSB
Storage Volume48 TB
Number of Items1
Compatible DevicesServer
Warranty DescriptionDescription
Full listing titleSynology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System

Ready to buy?

Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System is listed on Amazon. Price, availability, shipping and returns are set by Amazon and its sellers — check the listing for current terms. SpecPicks earns a small commission on qualifying purchases — thank you for supporting independent review work.

Buy on Amazon — $4,659.00

*Price sourced from Amazon.com. Last updated 2026-10-21. Price and availability subject to change.

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Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System
$4,659.00
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